Reversal of azole resistance in Candida albicans by oridonin
نویسندگان
چکیده
منابع مشابه
Proteomic analysis of azole resistance in Candida albicans clinical isolates.
Changes in protein expression within a matched set of Candida albicans isolates representing the acquisition of azole resistance were examined by two-dimensional polyacrylamide gel electrophoresis and peptide mass fingerprinting. Proteins differentially expressed in association with azole resistance included Grp2p, Ifd1p, Ifd4p, Ifd5p, and Erg10p, a protein involved in the ergosterol biosynthes...
متن کاملAzole Antifungal Resistance in Candida albicans and Emerging Non-albicans Candida Species
Within the limited antifungal armamentarium, the azole antifungals are the most frequent class used to treat Candida infections. Azole antifungals such as fluconazole are often preferred treatment for many Candida infections as they are inexpensive, exhibit limited toxicity, and are available for oral administration. There is, however, extensive documentation of intrinsic and developed resistan...
متن کاملMicafungin activity against Candida albicans with diverse azole resistance phenotypes.
OBJECTIVES The purpose of this study was to investigate whether mechanisms of azole resistance in Candida albicans contribute to reduced micafungin activity in vitro. METHODS MICs were determined for a collection of strains with well-characterized mechanisms of azole resistance obtained from systemic, oral and vaginal infections. This collection of strains includes those with resistance-assoc...
متن کاملGenetic analysis of azole resistance in the Darlington strain of Candida albicans.
High-level azole resistance in the Darlington strain of Candida albicans was investigated by gene replacement in C. albicans and expression in Saccharomyces cerevisiae. We sequenced the ERG11 gene, which encodes the sterol C(14)alpha-demethylase, from our copy of the Darlington strain. Both alleles contained the histidine for tyrosine substitution at position 132 (Y132H) reported in Darlington ...
متن کاملContribution of clinically derived mutations in ERG11 to azole resistance in Candida albicans.
In Candida albicans, the ERG11 gene encodes lanosterol demethylase, the target of the azole antifungals. Mutations in ERG11 that result in an amino acid substitution alter the abilities of the azoles to bind to and inhibit Erg11, resulting in resistance. Although ERG11 mutations have been observed in clinical isolates, the specific contributions of individual ERG11 mutations to azole resistance...
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ژورنال
عنوان ژورنال: Journal of Global Antimicrobial Resistance
سال: 2021
ISSN: 2213-7165
DOI: 10.1016/j.jgar.2020.10.025